Document Type
Article
Source Publication Title
Scientific Reports
First Page
1
Last Page
14
DOI
https://doi.org/10.1038/s41598-017-09375-y
Abstract
Copper Cysteamine (Cu-Cy) is a new photosensitizer and a novel radiosensitizer that can be activated by light, X-ray and microwave to produce singlet oxygen for cancer treatment. However, the killing mechanism of Cu-Cy nanoparticles on cancer cells is not clear yet and Cu-Cy nanoparticles as novel radiosensitizers have never been tested on colorectal cancers. Here, for the frst time, we investigate the treatment efciency of Cu-Cy nanoparticles on SW620 colorectal cells and elucidate the underlying mechanisms of the efects. The results show that X-ray activated Cu-Cy nanoparticles may kill SW620 cancerscells is in a dose-dependent manner. The JC-1 staining shows the mitochondrial membrane potential is decreased after the treatment. The observations confrm that Cu–Cy nanoparticles may improve X-ray radiotherapy on cancer treatment and X-ray activated Cu-Cy nanoparticles can be efciently destroy colorectal cancer cells by inducing apoptosis as well as autophagy. As a new type of radiosensitizers and photosensitizers, Cu-Cy nanoparticles have a good potential for colorectal cancer treatment and the discovery of autophagy induced by X-ray irradiated Cu-Cy nanoparticles sheds a good insight to the mechanism of Cu-Cy for cancer treatment as a new radiosensitizers.
Disciplines
Physical Sciences and Mathematics | Physics
Publication Date
8-24-2017
Language
English
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Liu, Zhipeng; Xiong, Li; Ouyang, Guoqing; Ma, Lun; Sahi, Sunil; Wang, Kunpeng; Lin, Liangwu; Huang, He; Miao, Xiongying; Chen, Wei; and Wen, Yu, "Investigation of Copper Cysteamine Nanoparticles as a New Type of Radiosensitiers for Colorectal Carcinoma Treatment" (2017). Physics Faculty Publications. 32.
https://mavmatrix.uta.edu/physics_facpubs/32