Graduation Semester and Year
2018
Language
English
Document Type
Thesis
Degree Name
Master of Science in Materials Science and Engineering
Department
Materials Science and Engineering
First Advisor
Fred Harry Tibbals
Second Advisor
Efstathios Meletis
Third Advisor
Yaowu Hao
Abstract
Bone disorders and disease are associated with multiple factors. Some of the disorders and diseases are difficult to understand because of their unknown root causes. Our goal was to differentiate between normal and genetically modified rat bone groups by finding the difference in mineral to matrix (Mn/Mx) content using Raman spectroscopy. Raman spectroscopy gives the chemical composition based on the vibration modes of the molecules. Quantitative analysis of Mn/Mx content calculated from Raman spectra allowed us to distinguish between healthy and genetically modified rat bone groups. We have presented the results by averaging the Mn/Mx ratios. Thus, the most significant result is the finding that mineral to matrix content is higher in bone in which the specific genetic bone growth factor was downregulated by disabling the gene. This higher mineral to matrix content in abnormal bones may indicate that this genetic factor primarily influences the growth of bone matrix, which gives the bone its toughness and flexibility.
Keywords
Raman spectroscopy, Mineral to matrix ratio, Characterization
Disciplines
Engineering | Materials Science and Engineering
License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
Recommended Citation
Shah, Meet Yagnesh, "CHARACTERIZATION OF NORMAL AND ABNORMAL BONES BY RAMAN SPECTROSCOPY : ANALYSIS OF MINERAL TO MATRIX RATIO OF BONE USING ADVANCED MATERIALS CHARACTERIZATION TECHNIQUES" (2018). Material Science and Engineering Theses. 133.
https://mavmatrix.uta.edu/materialscieng_theses/133
Comments
Degree granted by The University of Texas at Arlington