Microheater platform for selective detachment of DNA
Document Type
Article
Source Publication Title
Applied Physics Letters
First Page
93707
DOI
http://dx.doi.org/10.1063/1.4748308
Abstract
Despite deoxyribonucleic acid (DNA)’s well-known temperature sensitivity, not much work has been reported on leveraging temperature to manipulate the interaction of DNA with surfaces. This paper describes a microheater device that enables the application of a temperature field on a glass surface, thereby enabling the study of temperature-dependence of DNA-surface interactions. Experimental data for thermal performance of the device agree well with finite-element simulation results. Experiments demonstrate the capability of spatially selective detachment of DNA from a glass surface using the device. The integration of thermal-based capabilities described here with analysis tools such as polymerase chain reaction may help improve DNA detection and separation capabilities.
Disciplines
Electrical and Computer Engineering | Engineering
Publication Date
8-30-2012
Language
English
License
This work is licensed under a Creative Commons Attribution-Share Alike 4.0 International License.
Recommended Citation
Iqbal, Samir M.; Jain, Ankur; and Javed, Annas, "Microheater platform for selective detachment of DNA" (2012). Electrical Engineering Faculty Publications. 20.
https://mavmatrix.uta.edu/electricaleng_facpubs/20
