Fabrication and In Vitro Characterization of an Implant for the Detection of Metastatic Cancer Cells
Graduation Semester and Year
2018
Language
English
Document Type
Thesis
Degree Name
Master of Science in Biomedical Engineering
Department
Bioengineering
First Advisor
Liping Tang
Abstract
Greater than 90% of cancer related deaths are due to metastasis (Hayes & Wicha, 2011). Since current conventional techniques detect the disease by the time that it has become systemic, our lab has developed a hydrogel based cancer trap that can attract metastatic cancer cells via cytokine release. However, for continual monitoring and accessibility to the gel, an implant is needed for delivery, retention, and retrieval of the gel. The research undergone in this thesis seeks to develop such a method. Namely, the objective was to develop a polylactide (PLA) based implant that is capable of delivering and retaining a polyethylene glycol based gel, which is filled with cytokines for attracting metastatic cancer cells, in subcutaneous space for continual monitoring of the potential progression of localized cancer cells to a metastatic state.
Keywords
Medical devices, Tissue engineering, Implants, Cancer detection
Disciplines
Biomedical Engineering and Bioengineering | Engineering
License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
Recommended Citation
Cantu, Carlos Martin, "Fabrication and In Vitro Characterization of an Implant for the Detection of Metastatic Cancer Cells" (2018). Bioengineering Theses. 194.
https://mavmatrix.uta.edu/bioengineering_theses/194
Comments
Degree granted by The University of Texas at Arlington