Graduation Semester and Year
Fall 2024
Document Type
Dissertation
Degree Name
Doctor of Philosophy in Biomedical Engineering
Department
Bioengineering
First Advisor
Dr Kytai Nguyen
Second Advisor
Dr Juhyun Lee
Third Advisor
Dr Maham Rahimi
Fourth Advisor
Dr Liping Tang
Fifth Advisor
Dr Hao Xu
Abstract
Peripheral arterial disease (PAD) poses significant challenges due to arterial occlusions in the lower extremities, leading to acute ischemia and high morbidity and mortality rates. Current treatments such as stem cell therapy and surgical revascularization have limitations, including poor cell protection under hypoxia and long-time recovery in elderly patients. Advancing alternative therapies such as cell membrane-coated nanoparticles holds promise for targeted drug delivery by mimicking native environments to enhance treatment efficacy while minimizing systemic clearance and foreign reactions. These innovative strategies aim to optimize outcomes by prioritizing patient-centered approaches tailored to individual needs and preferences.
Towards that end, our long-term goal was to develop novel engineered pericyte membrane-coated nanoparticles (NPs) for targeted drug delivery to treat PAD. These nanoparticles, named TPM-DNPs, have a core made of poly(lactic-co-glycolic acid) (PLGA) and are loaded with Erythropoietin (Epo) protein. The core was further coated with membranes of cells engineered to express molecules binding with Intercellular Adhesion Molecule-1 alpha receptor (anti-ICAM1) to specifically achieve targeting and local delivery of payloads (therapeutic agents) and to establish Endothelial Cell (EC)-Pericyte interactions at the diseased sites, thereby promoting stemness, cell protection, proliferation, and angiogenesis for PAD treatment.
Keywords
ICAM1, Epo, membrane, Engineered membrane, targeted
Disciplines
Biological Engineering | Biomaterials | Biomedical Engineering and Bioengineering | Engineering | Other Biomedical Engineering and Bioengineering
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Iyer, Priyanka, "Engineered Pericyte Membrane-Coated Nanocarriers for Targeting Drug Delivery to Treat Peripheral Artery Disease" (2024). Bioengineering Dissertations. 195.
https://mavmatrix.uta.edu/bioengineering_dissertations/195
Included in
Biological Engineering Commons, Biomaterials Commons, Other Biomedical Engineering and Bioengineering Commons