ORCID Identifier(s)

0000-0002-1891-456X

Graduation Semester and Year

2020

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Mechanical Engineering

Department

Mechanical and Aerospace Engineering

First Advisor

Ashfaq Adnan

Abstract

Cavitation is a mechanism through which small vapor-filled cavities are formed in a liquid medium due to rapid changes of pressure. In liquid, the cavitation bubble is created when surrounding pressure drops below the saturation vapor pressure. Here, cavitation formation due to shock wave is considered. The molecular level heterogeneous and homogenous cavitation mechanisms and bubble growth kinetics in soft gelatin hydrogel and water has been studied. Gelatin, which is derived from collagen, is frequently used as a brain simulant material. As such, the morphology of gelatin is very different from water. In the heterogeneous cavitation study, using molecular dynamics simulation, the pressure requirement for nanoscale cavitation to grow in water and gel has been investigated. The results show that a gel-like structure requires higher pressure for the cavitation to grow, and both gel and water models exhibit a strain rate effects on the cavitation threshold pressure. The results also suggest that the cavitation collapse time is dominated by the viscosity of the medium. During the homogeneous cavitation study, the same model in the absence of preexisting bubble is stretched by volume-controlled stretching at six different strain rates. It is quite interesting to note that while critical tensile pressure for homogenous bubble nucleation of gel-like model is higher than the water at lower strain rates, at higher strain rate the critical pressure is quite similar, thus empirical relation cannot be obtained at much higher strain rate. The cavitation formation rate governs by the viscosity of the medium. In the second part of the study, ECM components such as Perineuronal net (PNN) which is one of the most prevalent components that surrounds the neuronal cell has been used to analyze the mechanics under shock loading. Assessment of the damage efficiency of the PNN molecules at different conditions such as shock speed, preexisting bubble, and boundary conditions have been considered. The change of the bonding morphology which is responsible for the stability of the secondary structure of the protein molecules of the PNN has been analyzed to evaluate the damage level.

Keywords

Cavitation, Molecular dynamic simulation, Extracellular matrix, Shock wave

Disciplines

Aerospace Engineering | Engineering | Mechanical Engineering

Comments

Degree granted by The University of Texas at Arlington

30885-2.zip (3715 kB)

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