Graduation Semester and Year

2015

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Mathematics

Department

Mathematics

First Advisor

Jianzhong Su

Abstract

How stress can affect human cognitive functions has been a very popular topic for researchers from different fields including physiology, psychology, biology, neuroscience, and applied mathematics. Hypothalamic−pituitary−adrenal (HPA) axis plays an important role in response to stress by releasing hormones, and level of glucocorticoid has been widely considered to be one key factor to distinguish people with different stress disorder. Emerging evidence has shown that glucocorticoid act on glutamate neurotransmission system and consequently influences neuronal activities’s cognitive function. It changes in the glutamate release and induces synapse plasticity change. Spike-Timing Dependent Plasticity (STDP) is one of the important neuroscience foundations for cognitive function. In this dissertation, we incorporate the HPA axis and CA1 neuron models to explore the plasticity outcome based on different type of stress. Various of spikes will be applied to test the Spike-TimingDependent Plasticity in different durations. The results in different facets show that CA1 neuron potentiation changes due to different stress input.

Disciplines

Mathematics | Physical Sciences and Mathematics

Comments

Degree granted by The University of Texas at Arlington

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Included in

Mathematics Commons

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