AMORPHOUS SILICON OXYNITRIDE COATINGS FOR CRANIOFACIAL IMPLANTS STIMULATE OSTEOGENESIS VIA NRF2 ANTIOXIDANT ACTIVITY

Author

Neelam Ahuja

ORCID Identifier(s)

0000-0002-6811-8924

Graduation Semester and Year

2022

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Kinesiology

Department

Kinesiology

First Advisor

Gopal Venu Varanasi

Abstract

Craniomaxillofacial injuries and defects are functionally and socially debilitating. These defects require immediate attention, and most cases undergo reconstruction surgery to restore the lost tissues. Current treatment strategies such as autologous bone grafts and fixative titanium devices are well established to treat the craniofacial region. But, the limited supply of donor bone and secondary surgery limit the use of autologous bone grafts, and low bioactivity, poor osteointegration of the titanium devices, has led to an increased number of tissue engineering research for the development of newer biomaterials. Bone defects especially in the craniofacial region can have a significant portion of bone tissue missing or lost and leaves the tissues ischemic, hypoxic and even contaminated. This leads to accumulation of reactive oxygen species, and the body’s homeostatic mechanisms fails. The oxidative stress makes these defects complex and compromised. In this study, we aim to target to reduce the unwanted oxidative stress to improve healing rates in bone. Prior studies have indicated the amorphous silicon oxynitride coatings created using plasma-enhanced chemical vapor deposition, shows leaching of the silicon ions which have a positive antioxidant effect and enhanced in vitro osteogenic biomarker expression. This study further investigates the bone defect healing for the silicon oxynitride coatings on titanium fixative devices in craniofacial region.

Keywords

Silicon oxynitride, Bone regeneration, Osteogenesis, Antioxidant biomaterials

Disciplines

Kinesiology | Life Sciences

License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

Comments

Degree granted by The University of Texas at Arlington

Recommended Citation

Ahuja, Neelam, "AMORPHOUS SILICON OXYNITRIDE COATINGS FOR CRANIOFACIAL IMPLANTS STIMULATE OSTEOGENESIS VIA NRF2 ANTIOXIDANT ACTIVITY" (2022). Kinesiology Dissertations. 29.
https://mavmatrix.uta.edu/kinesiology_dissertations/29