Document Type



Several drugs have a limited ability to dissolve in water, making it challenging for them to be absorbed by the body and reach their intended tissues. Although silicon can increase hydrophobicity it is not well known. By incorporating silicon into the drug's composition, its solubility and permeability will increase, enabling effective absorption and widespread distribution throughout the body. The goal of this research is the development of 4-silicon 1,7 heptene (diallylsilane) which incorporates silicon into its structure. The approach to achieve this goal will be to use dichlorosilane as an electrophile and react it with allyl magnesium bromide (CH2CHCH2MgBr), a nucleophile, to produce the target molecule. The results will be obtained through proton nuclear magnetic resonance spectroscopy (1H NMR). The compound will then be isolated by vacuum distillation. The compound will be useful in synthesis of bioactive chemicals, medicinally important compounds, and functional materials.

Publication Date



Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.