Document Type
Report
Abstract
Several drugs have a limited ability to dissolve in water, making it challenging for them to be absorbed by the body and reach their intended tissues. Although silicon can increase hydrophobicity it is not well known. By incorporating silicon into the drug's composition, its solubility and permeability will increase, enabling effective absorption and widespread distribution throughout the body. The goal of this research is the development of 4-silicon 1,7 heptene (diallylsilane) which incorporates silicon into its structure. The approach to achieve this goal will be to use dichlorosilane as an electrophile and react it with allyl magnesium bromide (CH2CHCH2MgBr), a nucleophile, to produce the target molecule. The results will be obtained through proton nuclear magnetic resonance spectroscopy (1H NMR). The compound will then be isolated by vacuum distillation. The compound will be useful in synthesis of bioactive chemicals, medicinally important compounds, and functional materials.
Publication Date
5-2024
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Asher, Sybil, "SYNTHESIS OF DIALLYL SILANE FOR BIOMEDICAL APPLICATIONS" (2024). 2024 Spring Honors Capstone Projects. 36.
https://mavmatrix.uta.edu/honors_spring2024/36