Graduation Semester and Year

2010

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Chemistry

Department

Chemistry and Biochemistry

First Advisor

Richard Guan

Abstract

This dissertation focuses toward finding two new avenues to explore the properties of ionic liquids (ILs). First, ILs has been used as a novel, and advantageous supporting electrolytes in nanopore stochastic sensing technology. Here, the sensing element is the alpha hemolysin protein, while a solution containing an ionic liquid will be used as the background electrolyte, instead of the typical used NaCl/KCl solution. This method employs single-channel recording with the planar lipid bilayer technique, where current modulation represents individual binding events. In this study, a useful means of implementing IL salt solutions will be demonstrated. Specifically, its great enhancements of sensitivity and selectivity of the nanopore for some analytes in stochastic sensing will be discussed. Further, the pH triggered ligand gating of alpha -hemolysin pore, by phosphonium IL will also be discussedThe goal of the second study is, use of IL as the stationary phase in capillary gas chromatography (GC), with thermal conductivity detector (TCD) for the detection of water content in liquid samples. The detection and quantitation of the amount of water in 50 different solvent samples, with increased sensitivity will be presented.

Disciplines

Chemistry | Physical Sciences and Mathematics

Comments

Degree granted by The University of Texas at Arlington

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