Graduation Semester and Year
2023
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy in Chemistry
Department
Chemistry and Biochemistry
First Advisor
Frank Foss
Abstract
Flavin adenine dinucleotide and flavin mononucleotide are co-enzymes with biologically relevant redox potentials. They are involved in many chemical transformation processes in the biological system, such as one-electron and two-electron transfer reactions, dehydrogenase reactions, and intramolecular electron transfer reactions critical to cellular function. Their ability to be reoxidized under aerobic conditions has inspired us to investigate biomimetic transformations with their derivatives, especially in converting NO2 to NO. Besides that, a series of biosensors was designed and investigated to detect NO in the aqueous system. NO sensors were achieved with computational DFT calculations correctly predicting the fluorescence response.
Keywords
Nitric oxide, Biosensor, Catalysts, Flavins, Oxidation, Oxidation reactions, Barium tagging, Barium sensor, Turn-on fluorescence, PET chemosensor, DFT, Computational chemistry, Cell bio-imaging
Disciplines
Chemistry | Physical Sciences and Mathematics
License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
Recommended Citation
Vuong, Thanh Thuy Thi, "Nitroalkane Oxidase Inspired NO-Transfer Agents, NO Sensors, and the Computational Design of Fluorescent Sensors" (2023). Chemistry & Biochemistry Dissertations. 196.
https://mavmatrix.uta.edu/chemistry_dissertations/196
Comments
Degree granted by The University of Texas at Arlington