Graduation Semester and Year
Summer 2024
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy in Chemistry
Department
Chemistry and Biochemistry
First Advisor
Frank Foss Jr
Abstract
Calixarenes are cyclic oligomers known for their unique molecular architecture that provides a versatile platform for applications in supramolecular chemistry. These molecules have exceptional binding ability to cations in solution, while also having multiple methods for tunability to change selectivity of cation. When coupled with fluorescent molecules, this serves as a binding domain which can be tuned to develop highly selective chemosensors. Neutrinoless double beta decay is a proposed particle phenomenon in which two neutrons spontaneously convert to two protons and eject 2 electrons, without the ejection of two neutrinos. In a model system, Xenon can be utilized as the element of interest, with Barium2+ being the product of decay. A sensor capable of detecting Ba2+ is critical to these experiments, with calixarenes providing a unique binding domain for this. Despite their opportunities, calix[4]arene preparation requires characterization of restricted rotomers. Due to their ability to rotate along their methylene axis, there are several possible conformations that can occur during their synthesis. Here, in chapter 2, we describe the synthesis and fluorescence studies of a calix[4]arene napthalimide based derivative for detection of Ba2+ in solution. We then detail several unconventional methods of determining structures of calix[4]arene derivatives post synthesis in chapter 3. Two unrelated projects are detailed in chapters 4 and 5. In chapter 4, we examine the isotopic labeling of cysteine derivatives. In chapter 5, we examine a method of trace analysis of pyrimidine antibiotics.
Keywords
Synthesis, Calixarene, Barium, Zinc, Cysteine, Pyrimidine, Fluorescence
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Madigan, Ryan P., "Calix[4]arene structure and Function in Sensors, Deuteration of Cystine Derivatives, and Purification of Pyrimidine-Based Antibiotics" (2024). Chemistry & Biochemistry Dissertations. 177.
https://mavmatrix.uta.edu/chemistry_dissertations/177