Document Type
Article
Source Publication Title
International Journal of Molecular Sciences
First Page
1
Last Page
14
DOI
http://dx.doi.org/10.3390/ijms18020323
Abstract
Simultaneous imaging of multiple targets (SIMT) in opaque biological tissues is an important goal for molecular imaging in the future. Multi-color fluorescence imaging in deep tissues is a promising technology to reach this goal. In this work, we developed a dual-modality imaging system by combining our recently developed ultrasound-switchable fluorescence (USF) imaging technology with the conventional ultrasound (US) B-mode imaging. This dual-modality system can simultaneously image tissue acoustic structure information and multi-color fluorophores in centimeter-deep tissue with comparable spatial resolutions. To conduct USF imaging on the same plane (i.e., x-z plane) as US imaging, we adopted two 90 -crossed ultrasound transducers with an overlapped focal region, while the US transducer (the third one) was positioned at the center of these two USF transducers. Thus, the axial resolution of USF is close to the lateral resolution, which allows a point-by-point USF scanning on the same plane as the US imaging. Both multi-color USF and ultrasound imaging of a tissue phantom were demonstrated.
Disciplines
Biomedical Engineering and Bioengineering | Engineering
Publication Date
2-4-2017
Language
English
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Kandukuri, Jayanth; Yu, Shuai; Cheng, Bingbing; Bandi, Venugopal; D’Souza, Francis; Nguyen, Kytai Truong; Hong, Yi; Yuan, Baohong; and Zweit, Jamal, "A Dual-Modality System for Both Multi-Color Ultrasound-Switchable Fluorescence and Ultrasound Imaging" (2017). Bioengineering Faculty Publications. 2.
https://mavmatrix.uta.edu/bioengineering_facpub/2