Graduation Semester and Year
2009
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy in Biomedical Engineering
Department
Bioengineering
First Advisor
Cheng-Jen Chuong
Abstract
Advancements in processing biomaterials have lead to the development of bioresorbable PLLA drug-loaded stents with different geometric configurations. To further advance the technology, systematic studies have been carried out. This dissertation consists of six specific aims: 1) To characterize the effects of thermal annealing on the mechanical characteristics of PLLA helical stent, 2) To characterize the mechanical characteristics of a PLLA double helix stent, 3) To characterize the physical and chemical properties of PLLA films impregnated with niacin and curcumin, 4) To characterize the mechanical interaction of expanded stent and vascular wall with both model simulation and experimental studies using PDMS phantom arteries, 5) To simulate the stent-plaque-artery interactions using computer models. Results and their significances in bioresorbable PLLA drug-loaded stents technology as well as clinical prospects will be presented.
Disciplines
Biomedical Engineering and Bioengineering | Engineering
License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
Recommended Citation
Welch, Tre Raymond, "Advances In Helical Stent Design And Fabrication: Studies Of Stent Thermal Treatment, Stent Mechanical Properties, And Stent Interactions With A Simulated Plaque-laden Artery" (2009). Bioengineering Dissertations. 22.
https://mavmatrix.uta.edu/bioengineering_dissertations/22
Comments
Degree granted by The University of Texas at Arlington