Ahmed Gure

Document Type

Honors Thesis


Currently, healthcare providers face significant challenges within the field of wound treatment. In the last decade, United Kingdom reported £2.3-3.1 billion expenditure on chronic wound treatments, whereas the United States spent over $25 billion on wound management. This indicates that unresolved wounds can place a significant burden on public health resources. A comprehensive review of global chronic wound pervasiveness found that the pooled prevalence of chronic wounds to be approximately 2.21 per 1000 individuals. Prevalence across the globe highlights the urgent need for more effective treatment strategies. One niche within the realm of wound treatment involves complementary and alternative medicines (CAMs), or treatments that are not involved in standard medical practice. This research aims to investigate the comparative impacts of CAMs including, boric acid (BA) and curcumin, with respect to wound healing in vitro. Wound infliction plays a major role in determining the effects of CAMs. In this research, we optimized the mode of wound infliction using various methods and found 1mL pipette stamp is highly effective in treating wounds in vitro and improves the feasibility of assessing wound closure more accurately. In our study, BA at a concentration of 10µM and curcumin with 1 µM-10 µM showed effective wound closure in mouse dermal fibroblasts. With respect to the cell proliferation, BA at a concentration of 1mM and curcumin from 0.5 µM-10 µM showed an increase in cell proliferation rates compared to the untreated control. These compounds offer alternative wound healing treatments on improving the migration and proliferation stage of the wound healing process in dermal fibroblasts. CAMs like these have the potential to expand the available repertoire of compounds for wound healing treatment methods along with improved cost efficiency.

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