Document Type

Honors Thesis


A current challenge in the healthcare field is the ability to continuously monitor blood analytes in real-time and with accuracy. The concentration of various blood analytes can change relatively quickly in critical care situations. The goal of this senior design project is to design a fiber optic biosensor that detects and analyzes specific proteins in the blood. In order to achieve this, a reservoir-receiver unit was designed to hold the fluid and the fibers were stripped, cleaved and spliced. The fiber tips were finally coated with the specific capture chemistries and connected with an SC connector to a phase-sensitive analyzing system. The protein of interest was laminin. Epoxy was used to create the reference gap for the analyzing system and was also used to bind laminin. A functional system was obtained with a spectral interference waveform that showed the binding of laminin to epoxy. This was visualized by an increase in the optical path length.

Publication Date






To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.