Julia Johnson

Document Type

Honors Thesis


Oxidative stress causes various cancers and tumors to arise in cells. These cause many mutations in normal cellular functions such as abnormal apoptosis and cell proliferation. To combat oxidative stress, Nrf2 factor helps by increasing antioxidants and reducing ROS (reactive oxygen species) and free radicals. Genes such as KEAP1, NQO1, GST and RXRa regulate Nrf2 by repression and activation. Expression of these four genes were observed in three reptilian species in the heart, kidney, liver and small intestine organs. In the Python bivittatus, KEAP1 and GST had significantly high gene expression. In Crotalus viridis NQO1 and GST were significantly high. In Nerodia rhombifer RXRa had the highest gene expression. This study can serve as an important factor in understanding oxidative stress, its relation to Nrf2 factor and the numerous genes that help regulate this pathway in living organisms.

Publication Date






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