Joanne Mai

Document Type

Honors Thesis


The determination of chronological age is complex and can be influenced by both genetic and environmental factors. Mitochondria, essential organelles that generate the vast amount of cellular energy, are closely associated with the aging process. While many studies have been performed, we still lack a complete understanding of how animal lifespan is determined. In the following research proposal, a strategy is outlined to uncover the mechanism of the mitochondrial unfolded protein response (UPRmt) and extended lifespan resulting from restriction of the amino acid methionine. The model organism Caenorhabditis elegans and a forward genetic screening strategy will be used to identify the genetic basis of methionine restriction-induced UPRmt. We predict that our findings will help explain the relationship of mitochondrial functional status to the aging process as it relates to the activation of stress responses such as the UPRmt.

Publication Date






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