Zeheng Li

Graduation Semester and Year




Document Type


Degree Name

Master of Science in Computer Science


Computer Science and Engineering

First Advisor

Junzhou Huang


Low-dose computed tomography (LDCT) has raised highly attention since the counterpart, full-dose computed tomography (FDCT), brings potential ionizing radiation influence to patients. However, LDCT still suffers from several issues such as relatively higher noise level, which limits its uses in practical applications. To improve LDCT image quality, conventional denoising methods, such as KSVD and BM3D, are first introduced to suppress noise in low-dose images. These methods, however, works under assumptions that are not robust to various data. In this paper, we conduct an extensive research on deep learning based denoising method in LDCT images. We mainly base on Generative-Adversarial Network (GAN) variants, such as CycleGAN, IdentityGAN and GAN-CIRCLE, and compare their performance in low-dose image denoising. Compared to supervised deep learning methods, these GAN based methods effectively learn image translation from the low-dose domain to the full-dose (FD) domain without the need of aligning FDCT and LDCT images, which is usually required in other methods for domain translation. Experiments on real and synthetic patient CT data show that these methods can achieve comparable peak signal-to-noise ratio (PSNR) and structural similarity index (SSIM) to, if not better than, the other state-of-the-art denoising methods. Among CycleGAN, IdentityGAN, and GAN-CIRCLE, the later achieves the best denoising performance with the shortest wall clock time. In addition, we use GAN-CIRCLE to demonstrate that the increasing number of training patches and training patients can improve denoising performance. Finally, two non-overlapping experiments, i.e., no counterparts of FDCT and LDCT images in the training data, further demonstrate the effectiveness of unpaired learning methods. This work paves the way for applying unpaired GAN based methods to enhance LDCT images without requiring aligned FD and low-dose images from the same patient.


Deep learning, GAN, CT denoising


Computer Sciences | Physical Sciences and Mathematics


Degree granted by The University of Texas at Arlington