ORCID Identifier(s)


Graduation Semester and Year




Document Type


Degree Name

Doctor of Philosophy in Computer Science


Computer Science and Engineering

First Advisor

Manfred Huber

Second Advisor

M Jacob Luber


This dissertation delves into the enhancement of biomedical image analysis through the deployment of artificial intelligence methodologies, focusing on the transition from theoretical innovation to practical clinical utility. Spanning four cornerstone projects, the work encapsulates the development of predictive models for spatial transcriptomics, efficient image compression for cancer pathology slides, and critical evaluations of histopathology slide search engines. The first project employs Random Forest Regression and spatial point processes to forecast cell distribution patterns, thereby offering a novel perspective on gene expression in embryogenesis at a single-molecule resolution. The second venture introduces a Variational Autoencoder (VAE) that sets a new precedent in histopathology imaging with a significant compression ratio, maintaining diagnostic reliability. Lastly, the third project assesses the performance of leading histopathology slide search engines, establishing a benchmark for their clinical application and suggesting enhancements for future integration. Together, these projects pave the way for AI-driven approaches to be woven into the fabric of clinical practice, signaling a transformative leap in the utility of biomedical imaging and multi-channel data interpretation


Artificial intelligence in biomedical imaging, Clinical Image analysis, Predictive models for pathology, Spatial transcriptomics, Histopathology data compression


Computer Sciences | Physical Sciences and Mathematics


Degree granted by The University of Texas at Arlington