Graduation Semester and Year

2018

Language

English

Document Type

Thesis

Degree Name

Master of Science in Biomedical Engineering

Department

Bioengineering

First Advisor

Liping Tang

Abstract

Greater than 90% of cancer related deaths are due to metastasis (Hayes & Wicha, 2011). Since current conventional techniques detect the disease by the time that it has become systemic, our lab has developed a hydrogel based cancer trap that can attract metastatic cancer cells via cytokine release. However, for continual monitoring and accessibility to the gel, an implant is needed for delivery, retention, and retrieval of the gel. The research undergone in this thesis seeks to develop such a method. Namely, the objective was to develop a polylactide (PLA) based implant that is capable of delivering and retaining a polyethylene glycol based gel, which is filled with cytokines for attracting metastatic cancer cells, in subcutaneous space for continual monitoring of the potential progression of localized cancer cells to a metastatic state.

Keywords

Medical devices, Tissue engineering, Implants, Cancer detection

Disciplines

Biomedical Engineering and Bioengineering | Engineering

Comments

Degree granted by The University of Texas at Arlington

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