Carlos Cruz

ORCID Identifier(s)

0009-0005-8958-1044

Graduation Semester and Year

2023

Language

English

Document Type

Thesis

Degree Name

Master of Science in Biomedical Engineering

Department

Bioengineering

First Advisor

Khosrow Behbehani

Abstract

An investigation on the use of rate pressure product (RPP) to measure the cardiac workload in sleep apnea patients is presented. RPP is the product of systolic blood pressure (SBP) and heart rate (HR). The application of RPP to quantify cardiac workload is combined with the detection of respiratory events occurring in close proximity (less than 30 seconds apart). These two combined factors provide a unique framework for analyzing sleep apnea events and are the primary novelty of the study. Close proximity events are referred to as respiratory event chains (RECs). Statistical analyses were conducted on various RPP metrics as well as SBP and HR to determine if there were significant differences between cardiovascular function during RECs and isolated events (greater than 30 seconds apart). The results show possible evidence of increased variability in RPP and SBP during REC events as compared to isolated events. However, these trends varied across subjects and the findings were inconclusive. Average RPP, HR, and SBP were not found to vary significantly between REC and isolated events. Correlation between the ratio of respiratory events to recovery, referred to as temporal event fraction ratio (TEFR), and RPP showed possible relationships between RPP variation and TEFR. But once again, the results are inconclusive and require further investigation.

Keywords

Rate pressure product, Sleep apnea, Cardiovascular

Disciplines

Biomedical Engineering and Bioengineering | Engineering

Comments

Degree granted by The University of Texas at Arlington

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