Maida Ranjbar

Graduation Semester and Year

2016

Language

English

Document Type

Thesis

Degree Name

Master of Science in Biomedical Engineering

Department

Bioengineering

First Advisor

Hanli Liu

Second Advisor

Ananth Madhuranthakam

Abstract

Respiratory induced motion artifacts, particularly those occurring in the abdomen and lung, pose a hefty problem in current diagnostic MR imaging. Application of images plagued with such artifacts not only hinder diagnosis, but may result in the enforcement of undesirably large safety margins in radiation therapy due to un-captured tumor characteristics that are concealed by the artifact. While several methods such as gated scans, breath-hold scans, variation of the K-Space acquisition trajectory, and reducing the scan time via partial acquisition or parallel imaging have been proposed as a solution, a robust and yet simple to implement remedy still remains to be proposed. This work investigates the application of partial K-Space acquisition/completion methods to correct for motion induced artifacts occurring in MR images of the abdomen; if feasible, the application of such methods to motion correction permits for the amelioration of the artifact ridden image, without a great deal of additional burdens in the clinical application of the imaging. Our study uses the mDIXON breath-hold sequence to image an abdomen phantom mounted on an MRI compatible motion platform, programmed by trajectories that mimic undesirable common motions such as coughs/hick-ups, constant inhale and exhale that often occur during breath-hold scans. By performing a parametric study of the resulting artifact to the parameters that characterize the programmed motion trajectory, we categorize the motion artifact in terms of the underlying motion that it originated from. A set of tools are then developed that permit for the manipulation, and correction of the K-Space and the resulting image. The developed set of tools provide a mechanism that permits for the study of the evolution of the image with the acquisition of the K-Space. Using our tools, regions in the K-Space that are acquired during the occurrence of the motion can be isolated, and manipulated to compensate for the motion. By applying our methodology to our experimental data obtained in the RTR 3T MR scanner, we show that even the simplest methods such as zero padding can lead to a reduction in the intensity of the observed artifacts, there-by permitting for an amelioration of the obtained image.

Keywords

Motion management, Breath-hold MRI scan, Respiratory motion correction, Parallel imaging and partial acquisition, K-Space correction, MRI compatible motion platform

Disciplines

Biomedical Engineering and Bioengineering | Engineering

Comments

Degree granted by The University of Texas at Arlington

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