Zengxing Pang

Graduation Semester and Year

2018

Language

English

Document Type

Thesis

Degree Name

Master of Science in Biomedical Engineering

Department

Bioengineering

First Advisor

Hanli Liu

Abstract

Light Reflectance Spectroscopy (LRS) is an imaging method that has shown increasingly promising evidence in its ability to detect various forms of cancer tissues. Our previous studies have illustrated the LRS modality’s capacity to differentiate normal and cancerous prostate tissues, specifically in its effectiveness in distinguishing cancer tissues classified 4+3 and 4+4 in Gleason Score. Despite having shown sufficient sensitivity and specificity towards prostate cancer detection, the pre-existing imaging system remains impractical for its intended clinical application of detecting positive surgical margins during prostatectomy. Two of the biggest challenges in the current equipment include lack of mobility and slow data collection, which stifles LRS’s advantage of being able to stream data in real time. This is largely due to the LRS fiber optic needle being fixed by a stationary clamp and being covered by a bulky black box as shielding from spectral noise from the environment. In this study, a novel handheld device was researched and developed to overcome the inconveniencing aspects of the LRS equipment, where the needle probe was placed into a 3D printed casing and utilized in a stylus fashion. This removed the need for the aforementioned stage and box shielding, which greatly enhanced the system’s mobility. Furthermore, a tactile switch was incorporated into the 3D printed device so that data could be streamed and collected without direct interaction with computer software, thus further increasing the user-friendliness of the modality. The effectiveness of this new approach was tested against the traditional set-up, and as a result, it was discovered that the newly developed device functions optimally in low light conditions. In addition, it was discovered that the enhanced system, due to being purely handheld, contains a higher magnitude of human error that results from inconsistently applied pressure. Therefore, further studies will be required to improve the consistency new LRS device before it can be transferred into direct clinical usage.

Keywords

Light reflectance spectroscopy, Radical prostatectomy, Prostate cancer, Positive surgical margins

Disciplines

Biomedical Engineering and Bioengineering | Engineering

Comments

Degree granted by The University of Texas at Arlington

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