Document Type
Article
Source Publication Title
The Open Biomedical Engineering Journal
First Page
28
Last Page
38
Abstract
Under physiological and pathological conditions, vascular smooth muscle cells (SMC) are exposed to different biochemical factors and biomechanical forces. Previous studies pertaining to SMC responses have not investigated the effects of both factors on SMCs. Thus, in our research we investigated the combined effects of growth factors like bFGF (basic fibroblast growth factor), TGF-�� (transforming growth factor ��) and PDGF (platelet-derived growth factor) along with physiological cyclic strain on SMC responses. Physiological cyclic strain (10% strain) significantly reduced SMC proliferation compared to static controls while addition of growth factors bFGF, TGF-�� or PDGF-AB had a positive influence on SMC growth compared to strain alone. Microarray analysis of SMCs exposed to these growth factors and cyclic strain showed that several bioactive genes (vascular endothelial growth factor, epidermal growth factor receptor, etc.) were altered upon exposure. Further work involving biochemical and pathological cyclic strain stimulation will help us better understand the role of cyclic strain and growth factors in vascular functions and development of vascular disorders.
Disciplines
Biomedical Engineering and Bioengineering | Engineering
Publication Date
1-1-2009
Language
English
License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License
Recommended Citation
Nguyen, Kytai Truong and Xu, Hao, "Effects of cyclic strain and growth factors on vascular smooth muscle cell responses" (2009). Bioengineering Faculty Publications. 30.
https://mavmatrix.uta.edu/bioengineering_facpub/30