Document Type
Article
Source Publication Title
Applied Physics Letters
DOI
http://dx.doi.org/10.1063/1.4737211
Abstract
The spatial resolution of fluorescence imaging techniques in deep optically turbid media such astissues is limited by photon diffusion. To break the diffusion limit and achieve high-resolution and deep-tissue fluorescence imaging, a fundamentally different method was demonstrated based on a concept of ultrasound-switchable fluorescence. The results showed that a small fluorescent tube with a diameter of 180 lm at a depth of 20mm in an optical scattering medium (l0 s 3:2 and la 0:026 cm 1) can be clearly imaged with a size of 260 lm. The depth-to-resolution ratio is shown to be about one order of magnitude better than other deep-tissue fluorescence imaging techniques.
Disciplines
Biomedical Engineering and Bioengineering | Engineering
Publication Date
1-1-2012
Language
English
License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
Recommended Citation
Liu, Yuan; Nguyen, Kytai Truong; Yuan, Baohong; and Alexandrakis, Georgios, "High-resolution imaging in a deep turbid medium based on an ultrasound-switchable fluorescence technique" (2012). Bioengineering Faculty Publications. 22.
https://mavmatrix.uta.edu/bioengineering_facpub/22