Graduation Semester and Year
2019
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy in Biomedical Engineering
Department
Bioengineering
First Advisor
Liping Tang
Second Advisor
He Dong
Abstract
Nanotechnology has been widely used in the field of biomedical engineering. For example, nanoparticles have been employed for targeted drug delivery due to their retention effect, increased permeability, site-specific targeting, and avoiding phagocytosis as foreign materials. Moreover, nanotools, such as liposomes, Q-dots, dendrimers, micelles, and carbon nanotubes, have been developed for disease diagnosis and treatment. Generally, the application of nanotechnology can be categorized as follows: nanomedicine, tissue regeneration, biomarker/biosensors, nanorobots, and gene therapy. In the past four years, I have been focusing on developing nanotechnology for diagnosis and treatment of many diseases such as osteoarthritis, open wound, and infection. Based on the work I have done, I published two articles in peer reviewed journals and had one manuscript in submission. All the abovementioned works are summarized in the following chapters. Chapter 1: Li S, Cong W, Hakamivala A, Huang Y, Borrelli J Jr, Tang L. Hyaluronic Acid-Based Optical Probe for the Diagnosis of Human Osteoarthritic Cartilage. Nanotheranostics 2018; 2(4):347-359. Chapter 2: Chen W, Li S, Renick PJ, Yang S, Pandey N, Boutte C, Nguyen KT, Tang L, Dong H. Bacterial Acidity-Triggered Antimicrobial Activity of Self-assembling Peptide Nanofibers. Journal of Materials Chemistry B. 2019; 7(18):2915-2919. Chapter 3: Li S, Zhou J, Huang Y, Roy J, Zhou N, Yum K, Sun X, Tang L. Injectable Click Chemistry-based Bioadhesives for Accelerated Wound Closure. Acta Biomaterialia. 2019 (under review). Chapter 4: Li S, Vu H, Senkowsky J, Hu W, Tang L. A near infrared fluorescent pH indicator film for wound milieu pH monitoring. Experimental Dermatology. 2019.
Keywords
Nanotechnology, Osteoarthritis, Antimicrobial, Bioadhesives, Wound pH.
Disciplines
Biomedical Engineering and Bioengineering | Engineering
License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
Recommended Citation
Li, Shuxin, "Development of medical devices for osteoarthritis diagnosis, antimicrobial, wound closure, and wound pH milieu monitoring" (2019). Bioengineering Dissertations. 25.
https://mavmatrix.uta.edu/bioengineering_dissertations/25
Comments
Degree granted by The University of Texas at Arlington