Shuxin Li

Graduation Semester and Year




Document Type


Degree Name

Doctor of Philosophy in Biomedical Engineering



First Advisor

Liping Tang

Second Advisor

He Dong


Nanotechnology has been widely used in the field of biomedical engineering. For example, nanoparticles have been employed for targeted drug delivery due to their retention effect, increased permeability, site-specific targeting, and avoiding phagocytosis as foreign materials. Moreover, nanotools, such as liposomes, Q-dots, dendrimers, micelles, and carbon nanotubes, have been developed for disease diagnosis and treatment. Generally, the application of nanotechnology can be categorized as follows: nanomedicine, tissue regeneration, biomarker/biosensors, nanorobots, and gene therapy. In the past four years, I have been focusing on developing nanotechnology for diagnosis and treatment of many diseases such as osteoarthritis, open wound, and infection. Based on the work I have done, I published two articles in peer reviewed journals and had one manuscript in submission. All the abovementioned works are summarized in the following chapters. Chapter 1: Li S, Cong W, Hakamivala A, Huang Y, Borrelli J Jr, Tang L. Hyaluronic Acid-Based Optical Probe for the Diagnosis of Human Osteoarthritic Cartilage. Nanotheranostics 2018; 2(4):347-359. Chapter 2: Chen W, Li S, Renick PJ, Yang S, Pandey N, Boutte C, Nguyen KT, Tang L, Dong H. Bacterial Acidity-Triggered Antimicrobial Activity of Self-assembling Peptide Nanofibers. Journal of Materials Chemistry B. 2019; 7(18):2915-2919. Chapter 3: Li S, Zhou J, Huang Y, Roy J, Zhou N, Yum K, Sun X, Tang L. Injectable Click Chemistry-based Bioadhesives for Accelerated Wound Closure. Acta Biomaterialia. 2019 (under review). Chapter 4: Li S, Vu H, Senkowsky J, Hu W, Tang L. A near infrared fluorescent pH indicator film for wound milieu pH monitoring. Experimental Dermatology. 2019.


Nanotechnology, Osteoarthritis, Antimicrobial, Bioadhesives, Wound pH.


Biomedical Engineering and Bioengineering | Engineering


Degree granted by The University of Texas at Arlington