Graduation Semester and Year

2011

Language

English

Document Type

Thesis

Degree Name

Master of Science in Biomedical Engineering

Department

Bioengineering

First Advisor

Samir M Iqbal

Abstract

Nanotechnology plays a major role in today's society due to its convergence of nanoscale which is the level of atoms and molecules as a part of miniaturization trend. The interference between biomedical and nanotechnology are of intense research. It concerns about the utilization of miniature biological systems such as nucleic acids, proteins, cells and cellular components to fabricate functional organic and inorganic nanostructures. This research work focuses on the process of developing a simple method to obtain fluorinated organic nanocoating which can be used to coat 3D structures and also explain the extended applications of the coating in the fields of biotechnology and medicine. These nanocoatings are made using two simple non-toxic chemistry and materials having different chemical and physical properties; 3-Aminopropyltrimethoxysilane (APTMS) and 1H, 1H, 2H, 2H- Perfluorooctyl-trichlorosilane (PFTS). The phenomenon is demonstrated using a simple vapor-phase approach which allows the monomers react in gaseous state and directly form the nanofilm. The main objective behind this work is to develop a simple time efficient and cost efficient method which helps in the deposition of nanolayers, over the pre-existing techniques which involve harsh chemical and plasma treatment such as Plasma polymerization, Chemical Vapor Deposition (CVD), biomineralization and Self Assembled Monolayers (SAM). Further, detailed research demonstrates about the two important goals of such coatings; biostability and biocompatibility; especially for the surfaces of medical implants. These properties are attained by modifying the surface characteristics of the substrates. With the help of chemical characterization and spectroscopic analysis, these nanocoatings were proved to be biostable and bio-compatible organic porous nanofilm making it applicable in biochemical/medical areas. Further research involves the formation of medicated nanocoatings which could be used to coat bio-implants which needs to have medicated surface.

Disciplines

Biomedical Engineering and Bioengineering | Engineering

Comments

Degree granted by The University of Texas at Arlington

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