ORCID Identifier(s)

0000-0001-7159-9477

Graduation Semester and Year

2021

Language

English

Document Type

Thesis

Degree Name

Master of Science in Biomedical Engineering

Department

Bioengineering

First Advisor

Michael Cho

Abstract

Diabetes mellitus is a chronic metabolic disease characterized by increased blood glucose levels and affects more than 8% of people worldwide (Rutter et. al, 2015). Typically, diabetes is divided into two large subcategories: type 1 diabetes (T1D) and type 2 diabetes (T2D). T1D is an autoimmune disorder caused by the attack of insulin secreting cells by t-cell mediated inflammatory response (Khrraoubi & Darwish, 2015). Currently, islet transplants offer a clinical treatment for restoration of glucose control. However, the current procedure may not be optimal as many transplanted islets do not survive because of the stresses induced during the process (Miki et. al, 2017). Photobiomodulation (PBM) has shown to have antioxidant capabilities in different cell types (Hamblin, 2017). Because a reduction of stress in islets may lead to improved functionality, PBM could enhance insulin secretion. Using mouse insulinoma -cells as a model, the current study is aimed at demonstrating the capability of PBM to increase the protective antioxidant activity and to validate an enhanced insulin secretion. Finally, we tested the hypothesis that the rates of photoenergy delivered to the cells modulate the PBM-induced effects in -cells.

Keywords

Photobiomodulation

Disciplines

Biomedical Engineering and Bioengineering | Engineering

Comments

Degree granted by The University of Texas at Arlington

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