ORCID Identifier(s)

0000-0002-6963-4779

Graduation Semester and Year

2016

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Physics and Applied Physics

Department

Physics

First Advisor

Wei Chen

Second Advisor

Yi Hong

Abstract

Photodynamic Therapy is a cancer treatment that requires a photosensitizer to reach a tumor in order to be excited by electromagnetic radiation sources so that the cancer killing agents such as Singlet Oxygen can be generated. In this work, the photosensitizer Protoporphyrin IX (PPIX) is improved with PS4VP nanoparticles to exhibit better photosensitive properties in aqueous solutions. Improvements include spectroscopic properties like absorption and photoluminescence emissions. In vitro studies showed better cell uptake, dark toxicity and photodynamic action, killing up to 85% of PC3 prostate cancer cells. Typical PPIX characteristics including photo-bleaching and photo-modification were also observed when nanoparticle variations were performed, where the photoproduct photoprotoporphyrin (PP) developed separate absorptions and emissions from PPIX. The rise of PP was also accompanied with singlet oxygen generation. After observing PPIX retaining properties and improved, the organic scintillator 2, 5-diphenyloxazole was added to the particle system and FRET was observed where PPO transferred energy from X-ray to excite PPIX and giving PPIX emission via X-ray.

Keywords

Photodynamic therapy, Photosensitizer Protoporphyrin IX (PPIX)

Disciplines

Physical Sciences and Mathematics | Physics

Comments

Degree granted by The University of Texas at Arlington

Included in

Physics Commons

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