Ifejola Adebo

Document Type

Honors Thesis


Heart valve disease is common in the world today and understanding the anatomical linkages, collagen, and elastin microstructures between the various heart valves is important for developing effective treatments. Four heart valves were gotten from the heart of a pig as they closely mimic the human heart. The purpose of this study was to analyze and compare the properties of the surrounding fibrous microenvironment of the tricuspid, mitral, pulmonary, and aortic valves after tissue clearing and imaging with a light-sheet microscope. The tissue clearing process entails procedures that render the samples transparent for in-depth imaging of the heart valves using the light sheet microscope, a technique that allows one to view the 3D imaging of a structure. Results gotten from these comparisons set the foundation for researchers and medical personnels to study the patterns of the valves for better diagnosis, surgical procedures, and treatment of heart valve diseases.

Publication Date




Faculty Mentor of Honors Project

Jun Liao



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