Document Type
Honors Thesis
Source Publication Title
EOR-1/PLZF-regulated WAH-1/AIF sequentially promotes early and late stages of non-apoptotic corpse removal
DOI
10.1101/2024.12.04.626465
Abstract
Programmed cell death (PCD) is an essential evolutionarily- conserved and genetically encoded program for normal development and homeostasis. A previous study identified a CED-3 dependent but mechanistically non-apoptotic and highly stereotyped elimination program called Compartmentalized Cell Elimination (CCE) in the C. elegans tail-spike epithelial cell (TSC). Here the transcription factor EOR-1/PLZF is found to promote CCE. The loss of which results in a persisting non-engulfed soma with enlarged nuclei in the first larval stage. This study finds that EOR-1 and its established partners function downstream of CED-3 Caspase protease activity, a role distinct from other PCD contexts where EOR-1 has previously been implicated.
Disciplines
Cell Biology | Developmental Biology
Publication Date
12-2024
Faculty Mentor of Honors Project
Piya Ghose
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Rather, Nathan, "The Role of EOR-1/PLZF in Promoting Soma Compartment Specific Death in a Non-Canonical Cell Death Program in C. elegans" (2024). 2024 Fall Honors Capstone Projects. 26.
https://mavmatrix.uta.edu/honors_fall2024/26
Comments
Piya Ghose is a Cancer Prevention Research Institute of Texas (CPRIT) Scholar in Cancer Research (RR100091) and is funded by a National Institutes of Health-National Institute of General Medical Sciences Maximizing Investigators’ Research Award (MIRA) (R35GM142489). Nathan Rather was supported by NIH SURF Supplemental Award 3R35GM142489-02S2.