ORCID Identifier(s)

ORCID 0009-0009-4583-0669

Graduation Semester and Year

Spring 2025

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Computer Science

Department

Computer Science and Engineering

First Advisor

Dajiang Zhu

Second Advisor

Junzhou Huang

Third Advisor

Li Wang

Fourth Advisor

Ming Li

Abstract

Artificial Intelligence (AI) is transforming healthcare by enabling large-scale analysis of medical data and integrating multimodal information for more comprehensive diagnostics. I present my work addressing fundamental and challenging problems in developing state-of-the-art AI models for medical data analysis, including multimodal brain data and other medical datasets. Additionally, I design brain-inspired AI models by integrating insights from organizational principles of brain networks. Specifically, my research tackles three critical aspects: (1) AI in Computational Neuroscience, where I design deep learning models for brain network analysis to uncover the organizational principles of brain networks; (2) Brain-Inspired AI, where I integrate superior brain organizational principles into AI model design and apply these brain-inspired AI models to downstream tasks; (3) Large Language Models (LLMs) for Healthcare, where I develop novel machine learning methods for LLMs to address healthcare challenges, including using LLMs for Alzheimer’s disease analysis. To assess the effectiveness of the proposed methods, I apply the developed models to a wide range of tasks and evaluate them across diverse datasets.

Keywords

Brain-inspired AI, Medical AI

Disciplines

Biomedical | Other Computer Engineering

License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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