Graduation Semester and Year

2009

Language

English

Document Type

Thesis

Degree Name

Master of Science in Chemistry

Department

Chemistry and Biochemistry

First Advisor

Daniel W Armstrong

Abstract

The focus of this thesis is on using state-of-the-art capillary electrophoresis (CE) in enantiomeric separations. Chapter 1 provides a brief introduction to enantiomeric separations using CE. Chapters 2 through 5 presents the use of different novel chiral selectors in CE. The selector properties and strategies for developing on enantiomeric separations are considered. Chapter 2 presents an overview on the most broadly useful chiral selectors for CE enantiomeric separations, sulfated cyclodextrins. Chapter 3 presents a new chiral selector, sodium arsenyl L-(+) tartrate. This chiral selector shows enantioselectivity for many amine-containing compounds and ruthenium (II) polypyridyl complexes and produces electropherograms with short to moderate migration times. Chapter 4 examines the CE enantiomeric separations of ten ruthenium (II) polypyridyl complexes using different types of cyclodextrin chiral selectors. Micellar capillary electrophoresis (MCE) was uilitized in this study. A comparison of the results using MCE to capillary zone electrophoresis (CZE) was discussed. Chapter 5 shows enantiomeric separations of almost 100 different amine-containing compounds using a new chiral selector, sulfated cyclofructan. Separations using the normal and reversed polarity mode were utilized in this study. Results from both separation modes were compared and discussed.

Disciplines

Chemistry | Physical Sciences and Mathematics

Comments

Degree granted by The University of Texas at Arlington

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