Graduation Semester and Year
Spring 2025
Document Type
Thesis
Degree Name
Master of Science in Chemistry
Department
Chemistry and Biochemistry
First Advisor
Subhrangsu S Mandal
Abstract
Inflammation is a natural biological response to harmful stimuli. It initiates a series of reactions that prompt defensive and curative mechanisms, ridding the body of offending agents and healing remaining injuries. Inflammation involves the intricate communication between cells, requiring complex signaling that mediates various pathways. This acute form of inflammation is vital for our survival, promoting a myriad of mechanisms that function to defend and heal. However, if this inflammatory response is not resolved, it results in a prolonged condition referred to as chronic inflammation. This persistent inflammatory state is incredibly harmful, damaging the host's healthy cells, tissues, and organs. When left unchecked, chronic inflammation can contribute to several illnesses, making it a primary therapeutic target for treatment. Resveratrol, a phytoalexin found in plants, has been previously studied for its potential anti-inflammatory and antioxidant effects. In this study, we investigated the effect of resveratrol on pro-inflammatory cytokines, reactive oxygen species (ROS), and other vital mediators of the immune response (NF-κB subunits). Resveratrol displayed a notable trend in a dose-dependent fashion, decreasing the production of known proinflammatory cytokines like IL-6 and TNFα as well as reducing nitric oxide (a type of ROS) levels. Chapter 1 gives a brief overview of immunity, vital signaling pathways, key cells of the immune system, and a general description of resveratrol to generate a greater understanding of the research conducted. Chapter 2 illustrates the effects resveratrol has on several proinflammatory mediators, providing further evidence of its anti-inflammatory and antioxidant properties.
Disciplines
Biochemistry | Molecular Biology
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Martinez, Valeria B., "Resveratrol Exerts Anti-Inflammatory Effects on Human THP-1 Macrophages" (2025). Chemistry & Biochemistry Theses. 117.
https://mavmatrix.uta.edu/chemistry_theses/117