ORCID Identifier(s)

0000-0001-8892-6833

Graduation Semester and Year

2023

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Chemistry

Department

Chemistry and Biochemistry

First Advisor

Frank Foss

Abstract

Flavin adenine dinucleotide and flavin mononucleotide are co-enzymes with biologically relevant redox potentials. They are involved in many chemical transformation processes in the biological system, such as one-electron and two-electron transfer reactions, dehydrogenase reactions, and intramolecular electron transfer reactions critical to cellular function. Their ability to be reoxidized under aerobic conditions has inspired us to investigate biomimetic transformations with their derivatives, especially in converting NO2 to NO. Besides that, a series of biosensors was designed and investigated to detect NO in the aqueous system. NO sensors were achieved with computational DFT calculations correctly predicting the fluorescence response.

Keywords

Nitric oxide, Biosensor, Catalysts, Flavins, Oxidation, Oxidation reactions, Barium tagging, Barium sensor, Turn-on fluorescence, PET chemosensor, DFT, Computational chemistry, Cell bio-imaging

Disciplines

Chemistry | Physical Sciences and Mathematics

Comments

Degree granted by The University of Texas at Arlington

Available for download on Tuesday, February 25, 2025

Included in

Chemistry Commons

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