ORCID Identifier(s)

0000-0002-6497-7190

Graduation Semester and Year

2019

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Chemistry

Department

Chemistry and Biochemistry

First Advisor

Liping Tang

Abstract

Modern technologies have been successfully identifying patient’s disease-related genetic information and developing effective drugs continuously. The discovery of molecular biomarkers paves new roads for potential individualized therapeutic applications; thus far, the call for a more development of advanced targeting/delivery platforms is highly required in the bioengineering field. Unfortunately, bioengineered targeting platforms for drug delivery at the right place, right dosage and right time have still remained in the developmental stages. To develop innovative nanosystems for various biomedical applications, polymer chemistry and click chemistry are needed to improve the function of the nanosystems. My dissertation research is based upon a unique mingling of chemistry and bioengineering. This platform is the perfect example of interdisciplinary research (IDR) and what modern technologies really needs. I believe that the new nanoplatforms and hydrogel scaffolds made here can be used, not only for specific targeting and diagnosis, but also for drug delivery and treatment of various diseases, including cancer, inflammatory disease and cardiovascular disease.

Keywords

Hydrogel polymeric nanoparticle, Click chemistry, Cancer trap, Inflammatory diseases, Cardiovascular diseases

Disciplines

Chemistry | Physical Sciences and Mathematics

Comments

Degree granted by The University of Texas at Arlington

Included in

Chemistry Commons

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