ORCID Identifier(s)

0000-0003-0048-9697

Graduation Semester and Year

2021

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Quantitative Biology

Department

Biology

First Advisor

Mark W Pellegrino

Abstract

Mitochondria are essential for energy production, metabolic signaling, calcium homeostasis, and other roles. Consequently, mitochondrial dysfunction can result in cellular decline and the onset of disease. Cells use the mitochondrial unfolded protein response (UPRmt) to facilitate the recovery of damaged mitochondria to restore homeostasis. Recent studies have shown that the UPRmt plays a vital role in tumorigenesis and cancer survival. Therefore, UPRmt inhibition may be used as an anticancer strategy with great therapeutic results. Moreover, a known paradigm exists between mitochondrial stress signaling and the regulation of organismal lifespan. Since the UPRmt is activated during mitochondrial stress, it is believed to be involved in the process of aging, albeit with some controversy. In addition to organismal aging, the UPRmt is associated with protecting the host during infection via the regulation of innate immunity. Understanding the mechanisms associated with UPRmt activation, therefore, has relevance to our fundamental understanding of mitochondrial recovery, as well as having potential practical applications in the biomedical field. With these implications in mind, my dissertation aims to investigate the regulation of the UPRmt using genetic and chemical means, using the model organism Caenorhabditis elegans.

Keywords

Mitochondria, Mitochondrial unfolded protein response (UPRmt), Caenorhabditis elegans (C. elegans), Worms, Lifespan

Disciplines

Biology | Life Sciences

Comments

Degree granted by The University of Texas at Arlington

Included in

Biology Commons

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